Synergistic effect of GEN and Flt1 peptide in the anti-angiogenesis effect results in a beneficial treatment of ocular neovascularization. This inhibitory effect on vascular permeability and corneal neovascularization was demonstrated in diabetic retinopathy and silver-nitrate cauterized corneas of SD rats respectively. This formulation was enabled to control drug release for 24 h. Here, FLT1 is linked to diabetic retinopathy.