KDR and acute lymphoblastic leukemia: Ponatinib, which targets PDGFR, VEGFR and FGFR, was initially approved for the treatment of refractory chronic myeloid leukemia (CML) or Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph + ALL) in 2012 (Pao et al., 2004; Cortes et al., 2018), then it entered two clinical trials in 2014 for the treatment of malignant neoplasm with FGFR fusions or activating mutations (NCT02265341, NCT02272998).