As shown in Table 1, the expression levels of cx3cl1 and CCL28 in 40 patients with spinal bone metastasis of lung adenocarcinoma were significantly correlated with ECOG score (P = 0.005) and visceral organ metastasis (P = 0.004), but not with age, gender, number of bone metastasis, and chemotherapy (P > 0.05). This evidence concerns the gene CX3CL1 and bone metastasis.