PGF and preeclampsia: We showed that (i) the ECM is oxidized in placentas derived from patients with a late onset preeclampsia diagnosis which is further confirmed by the detection of changes of expression of two major oxidation markers 3-chlorotyrosine and 3-nitrotyrosine, (ii) this oxidized environment led to change of trophoblast proliferation, migration, and apoptosis, as well as a decrease of Placental Growth Factor and Transforming Growth Factor β expression, (iii) an application of 670 nm light reversed the permutations of late onset pre-E.