Besides, this pathway is a downstream signal that is activated via the BCR–ABL kinase, which is suggested to play an indispensable role in CML cell survival mediated by BCR–ABL.24 Therefore, it was postulated in this study that the PI3K/Akt signal transduction pathway participated in the association of HDAC2 with the apoptosis of CML cells resistant to IM. The gene discussed is BCR; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.