So far, ABCB5 has mostly been described in cancer, where it was associated with tumor invasiveness, metastasis, angiogenesis, and drug resistance (Cheung et al., 2011; Frank et al., 2005; Frank et al., 2011; Guo et al., 2018), supporting our findings for its role also in neovessel formation in the context of atherosclerotic plaque instability. The gene discussed is ABCB5; the disease is cancer.