HBB and malaria: Most evidence has focused on well-established examples, such as the sickle-cell trait protecting against severe malaria in individuals heterozygous for the beta-globin (HBB) sickle-cell allele, glucose-6-phosphate dehydrogenase (G6PD), and the major histocompatibility complex (MHC) region (Key et al., 2014; Solberg et al., 2008).