According to the correlation analysis between SRSF3 and immune checkpoint gene expression, it can be found that SRSF3 is closely related to TNFSF14, TNFRSF14, TNFRSF25, CD276, NRP1, VSIR in a variety of malignant tumors (P <0.05). The gene discussed is TNFRSF14; the disease is cancer.