The result of immunoprecipitation assay showed that the endogenous CK1δ, CK1ε, β-catenin and Tip60 proteins were immunoprecipitated with an anti-β-catenin antibody in SW480 and HCT116 cells (Figures 4A, B), suggesting that the CK1δ/CK1ε/β-catenin/Tip60 complex existed in colon cancer cells. This evidence concerns the gene KAT5 and malignant colon neoplasm.