Considering that CK1δ and CK1ε are highly expressed in colon cancer, which is involved in advanced progression and poor prognosis (34, 41, 42), two colon cancer cell lines SW480 and HCT116 were employed to examine the interaction among CK1δ/ε, β-catenin and Tip60. Here, KAT5 is linked to malignant colon neoplasm.