In order to verify whether canonical WNT signaling is involved in DLBCL-induced EndMT, IWR-1 (an inhibitor of the canonical WNT signaling) was added into the co-culture system, and downregulation of β-catenin protein level proved that IWR-1 treatment worked in inhibiting the canonical WNT signaling. The gene discussed is SLC7A6OS; the disease is diffuse large B-cell lymphoma.