Tumor biogenesis is a complex progress involving multiple genes, and HOXC10 (22), UFM1 (23), EGR1 (24), MDGA2 (25), and CLDN18 (26) have been proved to be biomarkers of GC, but the pathogenesis and mechanism of GC have not been clarified. The gene discussed is EGR1; the disease is neoplasm.