Interestingly, when reviewing patients with family history of cancers, we found that these patients were more likely to harbor hereditary deleterious mutations in genes involving in homologous recombination DNA repair pathways including BRCA1, BRCA2, CHEK2, BARD1, FANCC, FANCM, and RAD50 than patients without family history of cancer (Figure 4D and Table 2). Here, CHEK2 is linked to cancer.