Subsequently, the dysregulation of EGFL7 has been found in a variety of tumors, including lung cancer (13), hepatocellular carcinoma (14), acute myeloid leukemia (15) and malignant pleural mesothelioma (16), suggesting that EGFL7 participates in tumorigenesis through a wide range of effects. The gene discussed is EGFL7; the disease is malignant pleural mesothelioma.