In the current study, we found that the expression of miR-126 and EGFL7 mRNA was concomitantly downregulated through the methylation of CpG islands in NSCLC and that the eQTL-missense polymorphism of EGFL7, rs2297538 (located at 386 bp 5’ of miR-126), was significantly associated with the risk of NSCLC in the Han Chinese population. Here, EGFL7 is linked to non-small cell lung carcinoma.