Recent studies have revealed that single nucleotide polymorphisms (SNPs) in gene regulatory and coding regions could confer risk of lung cancer by regulating the expression of specific genes (26–28), hinting that SNPs in the transcriptional regulatory region and coding region of EGFL7 might also play a role in the regulation of EGFL7 and miR-126 expression, and be further involved in NSCLC susceptibility. The gene discussed is EGFL7; the disease is non-small cell lung carcinoma.