VWA5B2 and brain ischemia: miR-1224, located at chromosome 3q27.1, is a class of mammalian mirtron encompassed in the last intron of the VWA5B2 gene (von Willebrand factor A domain containing 5B2) and is discovered that acts vital roles in some diseases, such as acute liver failure, Parkinson’s disease, and cerebral ischemia (13–15).