RBM15B and hepatocellular carcinoma: RBM15B knockdown increased the inhibition rate of sorafenib in the sorafenib-resistant HCC-LM3R and Huh-7R cell lines and decreased IC50 value, while in Hep-G2R cells overexpressing RBM15B, the inhibition rate was lower, and the IC50 value was higher (Figures 3C, D).