Subsequently, a study by Koche et al. showed the amplification and circularization of many neuroblastoma-related genes in eccDNA, such as MYCN, Jun proto-oncogene (JUN), MDM2 proto-oncogene (MDM2), SRY-box transcription factor 11 (SOX11), and T-cell acute lymphocytic leukemia 2 (TAL2). The gene discussed is MDM2; the disease is neuroblastoma.