CD4 and acute myeloid leukemia: In addition, we assessed the TIM-3 expression of CD8+ and CD4+ T lymphocytes in the bone marrow of these AML patients, and both of them correlated positively with that of leukemic blasts (CD8+ T cells: R2 = 0.44, p<0.0001; CD4+ T cells: R2 = 0.16, p=0.0181) (Figures 1C, D).