Silva et al. reported that latrophilin1/protein kinase C/mammalian target of rapamycin pathway was involved in the expression of TIM-3 and its ligand Gal-9 in AML blasts, but all their experiments were performed in the cell line of THP-1, which carries KMT2A-MLLT3 fusion gene rather than CBF translocations (12). This evidence concerns the gene HAVCR2 and acute myeloid leukemia.