HAVCR2 and acute myeloid leukemia: In the peripheral blood of AML patients, TIM-3 expresses not only in leukemic blasts, but also in multiple other cell types, e.g. T lymphocytes, NK cells, monocytes, etc. However, leukemic blasts are the main cell population (average percentage of 39.6% in non-M3 AML patients of TCGA data), and our data also showed that TIM-3 expression of T cells, another big cell population, correlated positively with that of leukemic blasts, therefore TIM-3 mRNA expression in the peripheral blood is supposed to represent that of leukemic blasts.