EGF and breast cancer: SK-BR-3, an epithelial like breast cancer cell line, can be induced to go through EMT by EGF stimulation, and show a low baseline expression of SRGN. We therefore examined SRGN expression in SK-BR-3 during EMT and found that SRGN was induced by EGF treatment together with N-cadherin (CDH2) and ZEB1 (Figure 3D).