The serglycin/CD44 signaling axis induces the expression of Nanog and activates NF-κB/claudin-1 axis in NSCLC (70) and triggers MAPK/β-catenin signaling in nasopharyngeal cancer cells (71) to foster EMT, cancer cell stemness, and drug resistance. This evidence concerns the gene CLDN1 and non-small cell lung carcinoma.