GPX4 and pancreatic adenocarcinoma: Kaplan-Meier overall survival curves, which were based on OTUB1, SLC7A11 and GPX4 levels from the TCGA PAAD database confirmed that patients with high expressions of OTUB1, SLC7A11 and GPX4 had significantly low survival outcomes, relative to those with low expressions (Supplementary Figure 1C).