According to the literature, PDGF-BB exerts no effects on the proliferation of tumor cells but enhances the invasion and metastasis of tumor cells through matrigel in vivo, resulting in PDGFR-β-mediated phosphorylation of MUC1 cytoplasmic tail (MUC1CT) to regulate the invasiveness of PC cells. The gene discussed is PDGFRB; the disease is pachyonychia congenita.