CXCR1 and neoplasm: Furthermore, tumor-produced CXCR1 and CXCR2 chemokine receptor agonists induce neutrophils and granulocyte myeloid-derived suppressor cells (MDSCs) to generate NETs that encapsulate tumor cells and protect them from the cytotoxicity of CD8+ T cells and NK cells by hindering the contact between immune cells and surrounding target cells (130).