Recent research has demonstrated that miR-221-5p, miR-29a-3p, miR-22-3p and miR-17-3p were abundant in platelets of PC patients, and miR-29a-3p could inhibit the expression of SPARC, a multifunctional glycoprotein, and promoted proliferation, migration and invasion of PC cells in vitro (91). Here, SPARC is linked to pachyonychia congenita.