KED (Lys-Glu-Asp) (Khavinson et al., 2021), EDR (Glu-Asp-Arg) (Khavinson et al., 2020), and GPE (Gly-Pro-Glu) (Turkez et al., 2021) were found to prevent dendritic spines loss and neuroplasticity impairments in both in vitro and in vivo models of AD although they have different amino acid compositions. Here, PEG10 is linked to Alzheimer disease.