MAPT and Alzheimer disease: With the pathological features of amyloid-beta (Aβ) plaque and neurofibrillary tangle (NFT) in the human AD brain (Scheltens et al., 2016), AD is widely believed to be triggered by the production and accumulation of Aβ and hyperphosphorylated tau (p-tau) (Viola and Klein, 2015; Congdon and Sigurdsson, 2018).