Compared with those in the WT group, the expression of GFAP in the hippocampus and frontal cortex in the AD group, ADS group and ADT group were significantly higher (P < 0.001), but the expression of GFAP in the hippocampus and frontal cortex in the ADT group were significantly lower than those in the AD group and ADS group (P < 0.001). This evidence concerns the gene GFAP and Alzheimer disease.