Compared with the WT group, The expression of PDGFRβ in the hippocampus and frontal cortex in the AD group, ADS group and ADT group were significantly lower (P < 0.001), while compared with the AD group and ADS group, the expression of PDGFRβ in the ADT group were significantly increased (P < 0.001). Here, PDGFRB is linked to Alzheimer disease.