In terms of metabolism, previous studies that explored the independent and reciprocal effects of curcumin on the brain and liver have shown that curcumin injection prior to Aβ deposition can prevent AD in APP/PS1 mice, suggesting that curcumin may significantly affect the elimination of Aβ42 in cerebral blood transport and peripheral circulation (Yepes, 2021). This evidence concerns the gene APP and Alzheimer disease.