More studies devoted to the association analysis of AD-PRS and these biomarkers found that AD-PRS was not only correlated with the CSF levels of Aβ42, Aβ42/Aβ40, T-tau, and P-tau in the older adults (Porter et al., 2018a; Li et al., 2020), but could also predict the incidence rate of LOAD and the age at onset (Li et al., 2020). The gene discussed is MAPT; the disease is Alzheimer disease.