SMPD1 and cancer: Siramesine, as a lysosomotropic detergent, was confirmed to inhibit acid sphingomyelinase and trigger lysosomal cell death, which can kill cancer cells from the inside.6 Compared with traditional DNA damage drugs such as doxorubicin9 and camptothecin,10 siramesine can reduce the damage of chemotherapy to normal tissue, which has some enlightenment for the development of cancer treatment based on the combination of lysosomal reagent and nanomaterials.