Dual immunofluorescence for NF-κB and the microglial marker IBA-1 in rats in the control group, EP group, epilepsy+BAY 11–7082 (EP+BAY) group, epilepsy+TAK242 (EP+ TAK) group, 2 days after SE, NF-κB expression in hippocampal CA1, CA3, and DG microglias were low in rats in the control group, and NF-κB expression was significantly increased in rats in the EP group. The gene discussed is NFKB1; the disease is epilepsy.