The multivariate logistic regression analysis showed that number of clinical symptoms [odds ratio (OR) 0.25, 95% CI 0.09–0.68, and p = 0.007], mental behavior disorder (OR 0.07, 95% CI 0.02–0.36, and p = 0.001), central hypoventilation (OR 0.04, 95% CI 0.00–0.56, and p = 0.017), maximum mRS score (OR 9.12, 95% CI 2.40–34.66, and p = 0.001), and albumin level (OR 0.85, 95% CI 0.75–0.96, and p = 0.010) were significantly associated with non-response to short-term first-line treatment. This evidence concerns the gene ALB and Central hypoventilation.