In the same way, hyperinsulinemia and reduced glucose uptake insulin-stimulated and expression of total and phosphorylated specific insulin-signaling proteins in skeletal muscle have also been demonstrated in male and female offspring at 15 and 21 months old, respectively, indicating an insulin-resistance state induced by maternal LPD during pregnancy (Fernandez-Twinn et al., 2005). The gene discussed is INS; the disease is hyperinsulinism.