KAT2A can regulate gene transactivation via H3K9ac and H3K14ac and significantly upregulate target superoxide dismutase 2 (SOD2) mitochondrial in ETBF-infected CRC cells via directly binding to the promoter region of SOD2 (Sun et al., 2016; Cao et al., 2021). This evidence concerns the gene SOD2 and colorectal carcinoma.