IFNB1 and multiple sclerosis: For the treatment of multiple sclerosis by IFN-β-loaded controlled-release composites, microcarrier was synthesized using trimethyl-chitosan, poly(ethylene glycol)dimethacrylate and methacrylic acid in free radical suspension polymerization.9 The formed pH-sensitive microparticles were tested after oral administration in rabbits, and 24 h sustained IFN-β was achieved accompanying with higher plasma concentration level compared with the subcutaneously injected IFN-β.