SLC40A1 and Iron deficiency anemia: Under conditions of iron deficiency, irp1/2 bind to the IRE located at the 5’UTR of ft-h, ft-l and ireg1 mRNAs, repressing their translation, while their binding to the IREs of the 3’UTR stabilize the tfr and dmt1 transcripts, preventing their degradation and increasing iron uptake.