CGAS and melanoma: A study on IFI16/IFI204 methylation in melanoma reported that PRMT5 methylated R12 in the PYRIN (protein-protein interaction) domain of IFI204 via a PRMT5-SHARPIN interaction, which attenuated IFI204 binding with dsDNA, restrained dsDNA-stimulated activation of cGAS/STING signaling, and limited subsequent IFN-β and chemokine production by the TBK1-IRF3 pathway (19).