Timothy Chan team performed a comprehensive analysis of multiple biological factors (TMB, copy number change score, HLA-1 evolutionary difference, HLA-1 loss of heterozygosity, MSI, BMI, gender, NLR, tumor stage, immunotherapy drugs, age, tumor type, chemotherapy before immunotherapy, and blood indicators such as albumin, platelets and hemoglobin) (100) . This evidence concerns the gene ALB and neoplasm.