To further extend our understanding of CD8+Ly49+ Foxp3neg Treg in autoimmunity, a group demonstrated that clonally expanded CD8+Ly49+ T cells in a model of experimental autoimmune encephalitis (EAE) represent a CD8+Ly49+Foxp3neg Treg subset that is non-responsive to myelin protein but is instead suppressive towards autoreactive CD4+ T cells. The gene discussed is CD8A; the disease is Autoimmunity.