ITGAE and systemic lupus erythematosus: While TGF-β has been shown to drive the induction of CD103 expression in CD8+ iTreg, which in some circumstances has been shown to be a simultaneously cytotoxic and immunosuppressive T-cell subset (46), IL-10 has also demonstrated cytolytic characteristics during systemic lupus erythematosus (SLE) (47–49).