PRDX5 and selenium deficiency: Replenishing the nutritional status of the host by (a) increasing vital amino acids such as cysteine and/or (b) providing GSH itself, through liposomal administration (14) to enhance GSH levels, and (c) supplementing selenium to improve selenium deficiency and facilitate selenoprotein (GSH peroxidases, thioredoxin reductases) expression (15) can inhibit oxidative stress, modulating inflammation and endothelial dysfunction.