Recombinant SARS-CoV-2 spike protein has been observed to directly bind K18-hACE2 platelets and potentiate thrombosis formation in wild-type mice following K18-hACE2 platelets transfusion (2), albeit using concentrations of spike protein that greatly exceed the concentration of S1 subunit observed in sera of individuals with COVID-19 (4) or following mRNA-1273 vaccination (24). The gene discussed is PSMD1; the disease is COVID-19.