IGFBP2 and central nervous system cancer: We verified the expression of seven core molecules at the tissue levels, and the results showed that the expression of five molecules (VAMP, SVOP, Transgelin2, VIM, METTL7B) in glioma tissues was significantly higher than that in adjacent tissues, while the expression of TNR was on the contrary, and IGFBP2 had no significant significance (Figure 9A).