The meta-analyses results show that 12 variants in the IL6R gene are significantly associated with risk of CVDs (CAD, coronary heart disease, atrial fibrillation, aneurysms, and atherosclerosis), inflammatory or autoimmune diseases (rheumatoid arthritis, asthma, Crohn’s disease, ulcerative colitis, dermatitis, and type 1 diabetes), and levels of inflammatory biomarkers (CRP, fibrinogen, IL-6, IL-6R, and sIL-6R). This evidence concerns the gene CRP and atrial fibrillation.