In addition, the variant rs4845625 (T allele) strongly associated with CAD is in weak or moderate LD with rs2228145 (r2 = 0.04, 0.462, and 0.63 in African, European, and Asian populations, respectively), reflecting that functional mechanisms of IL6R variants associated with CVD risk might be distinct. The gene discussed is IL6R; the disease is coronary artery disorder.