Moreover, the oncolytic cell burst promotes immunogenic cell death (ICD), with the release of several cellular factors known as damage-associated molecular patterns (DAMPs) such as calreticulin (ecto-CRT), secreted adenosine triphosphate (ATP) and high mobility group box 1 protein (HMGB1), enhancing the anti-tumor immunity (22–24). This evidence concerns the gene CALR and neoplasm.