CD8A and cancer: The reaction requires only 15 minutes and several studies have shown its anti-tumor efficacy and immunological modulation in different contexts and tumor models such as murine triple-negative breast cancer (34), as a cancer therapeutic platform for immunopeptidomic pipelines (7, 35), as a tool to explore viral mimicry to tumor antigens for cancer immunotherapy (36), as a platform to exploit pre-existing immunity to pathogens for boosting anti-tumoral CD8 T cell response (37) or to decorate with tumor peptides OAd encoding immunostimulatory molecules (38).