MCL1 and Cowden disease: However, there are still two questions: (1) the authors determined Mcl-1 as the target of miR-29b, but did not explain why IL6 or IL-8 surmounts miR-29b to direct downregulation of Mcl-1; (2) the author brought up the idea that Mcl-1 is an anti-apoptotic gene, but did not clearly describe its corresponding role in CD intestinal fibrosis.