CHIP has already been linked to various neurodegenerative diseases, such as polyQ disorders, Parkinson’s disease, and Alzheimer’s disease (Miller et al., 2005; Kumar et al., 2012; Momtaz et al., 2020; Mylvaganam et al., 2021; Potjewyd and Axtman, 2021). This evidence concerns the gene STUB1 and early-onset autosomal dominant Alzheimer disease.