In an experiment using a mouse model of NASH, LCN-2 in the systemic upregulates the expression of the LCN-2 receptor (24p3R) in brain cells and secretes the damage-associated molecular pattern protein (DAMP), a high mobility group box 1 (HMGB1) that subsequently induces oxidative stress and nod-like receptor protein 3 (NLRP3) inflammasome activation on the brain cells (Mondal et al., 2020). The gene discussed is HMGB1; the disease is metabolic dysfunction-associated steatohepatitis.