Unlike other CNS diseases, a stroke leads to the death of numerous brain cells (Lee et al., 2007, 2012; Bi et al., 2013; Jang et al., 2013a; Jin et al., 2014a, b; Wang et al., 2015; Kim et al., 2016, 2017; Bhusal et al., 2019; Chen et al., 2019, 2020; Deng et al., 2019; Braga et al., 2020), which can be directly or indirectly mediated by LCN-2. The gene discussed is LCN2; the disease is Stroke.