CISD2 expression was observably related to CD8A of CD8+ T cells, IRF5 of M1, MS4A4A of M2, CCR7 of neutrophils, STAT1 of Th1, STAT5A of Th2, and STAT5B of Treg in LGG and GBM. The gene discussed is CISD2; the disease is glioblastoma.