In the univariate Cox regression analysis, we found that the high expression of BUB1 (hazard ratio (HR) = 1.16125, 95%confidence interval (CI): 1.00955, 1.33575, p = 0.03634) and BUB1B (HR = 1.19911, 95% CI: 1.03011, 1.39585, p = 0.01915) suggested that BrCa patients had poor progression-free survival (PFS). This evidence concerns the gene BUB1B and invasive breast carcinoma.