Notably, the ac4Cscore high group predominated in the immune subtypes IFN-gamma Dominant and Wound Healing, which were classified as having increased expression of angiogenic genes and a higher proliferation rate, while the ac4Cscore low group was mainly attributed to subtype Inflammatory, defined as low to moderate tumor cell proliferation (Thorsson et al., 2018). The gene discussed is IFNG; the disease is neoplasm.