KDM5D and metastatic malignant neoplasm in the lymph nodes: In addition, related studies have shown that the expression of ETV4 is significantly increased in the process of gastric cancer cell proliferation and is closely related to lymph node metastasis, distant metastasis, and poor prognosis of gastric cancer patients, while KDM5D can downregulate the expression of ETV4 (Cai et al., 2020).