BRCA1 and neoplasm: In addition, in syngeneic mouse breast tumor models and xenotransplantation models, KDM5B knockout leads to upregulation of tumor suppressor genes such as BRCA1, CAV1, and HOXA5 (Yamane et al., 2007) and increased H3K4 methylation in the chromatin regions of these target genes (Rasmussen and Staller, 2014).