Related studies have shown that KDM5B inhibits the expression of PTEN at the transcriptional level through H3K4 demethylation, thus inhibiting phosphorylated PI3K and AKT and increasing the proliferation, migration and invasion of hepatocellular carcinoma cells in vivo and in vitro (Tang et al., 2015). The gene discussed is AKT1; the disease is hepatocellular carcinoma.