In summary, our results show that KDM5A/B/C is significantly overexpressed in a variety of tumor tissues, including PAAD, while the expression of KDM5D is significantly downregulated, indicating that the expression of KDM5 family members is closely related to the occurrence and development of many kinds of human malignant tumors, including pancreatic cancer. Here, KDM5A is linked to pancreatic adenocarcinoma.