Compared with that in paracancerous tissues or normal tissues, the expression of KDM5A/B/C was significantly increased in 12 kinds of tumor tissues, such as PAAD, breast invasive carcinoma (BRCA) and stomach adenocarcinoma (STAD), but significantly downregulated in only adrenocortical carcinoma (ACC) and skin cutaneous melanoma (SKCM) (Figures 1A–C). The gene discussed is KDM5A; the disease is invasive breast carcinoma.