In contrast, the expression of KDM5D was significantly decreased, and the expression level KDM5 family members was closely related to tumor stage, tumor grade, treatment efficacy, and other clinicopathological factors, suggesting that KDM5 family members have significant prognostic and diagnostic value and can be used as potential biomarkers for the diagnosis and prognostication of pancreatic cancer. This evidence concerns the gene KDM5D and familial pancreatic carcinoma.