Related experiments have shown that knockout of the KDM5B gene enhances the death of NSCLC cells induced by cisplatin and doxorubicin, suggesting that KDM5B may promote the invasiveness of NSCLC cells through epigenetic regulation of epithelial-mesenchymal transformation (EMT) regulatory factors such as vimentin, snail, and E-cadherin and upregulation of multipotent transcription factors such as OCT4, SOX2, KLF4, and c-Myc (Kristensen et al., 2012; Rasmussen and Staller, 2014; Yamamoto et al., 2014). The gene discussed is KLF4; the disease is non-small cell lung carcinoma.