The above results show that KDM5 family proteins may have strong interactions with HDAC1 and other proteins, modify the lysines of histone H3, and act on many pathways, including the “longevity-regulating pathway” and “Notch signaling pathway”, which play a regulatory role in the proliferation of pancreatic cancer cells. The gene discussed is HDAC1; the disease is familial pancreatic carcinoma.