MortaparibPlus (4-[ (1E)-2- (2-phenylindol-3-yl)-1-azavinyl]-1,2,4-triazole) is a novel synthetic small molecule that was isolated from a chemical library (12,000 molecules) after a high-throughput screening (HTS) assay based on two bioimage redistributive readouts [the shift of mortalin staining pattern from perinuclear (typical for cancer cells) to pan-cytoplasmic (typical for normal cells) and the stabilization, accumulation and nuclear enrichment of p53] (Putri et al., 2019). The gene discussed is HSPA9; the disease is cancer.