However, as shown in Figure 1, oncogenic signaling activation induces the p14ARF tumor suppressor to bind to MDM2 preventing its interaction with p53 (Weber et al., 1999; Pomerantz et al., 1998) leading to p53 post-translational modification, stabilization, and translocation to the nucleus to transactivate a set of genes responsible for the quite well-understood tumor suppression programs (apoptosis, cell cycle arrest and cell senescence). The gene discussed is TP53; the disease is neoplasm.