For example, Fengjing Wang et al. obtained two ESCC groups with different clinical survival outcomes from the transcriptome data of 179 ESCC cases and identified the corresponding biomarkers such as FOXA1 and EYA2 for subtype I and LAMC2 and KRT14 for subtype II (Wang et al., 2019b). Here, EYA2 is linked to esophageal squamous cell carcinoma.