Enhanced expression of Ror1 and/or Ror2 in cancer cells can promote their proliferation, migration, invasion, survival or chemoresistance through activation of Rho-family GTPases, c-Src, MAP kinases or Akt in Wnt5a-dependent and/or -independent manners (Enomoto et al., 2009; Zhang et al., 2012; Ida et al., 2016; Nishita et al., 2017; Hasan et al., 2019). This evidence concerns the gene ROR2 and cancer.