In the damaged kidneys from Ror2+/− mice, reduced disruption of the tubular basement membrane (TBM) along with reduced expression of MMP-2 in tubular epithelial cells were observed compared to Ror2+/+ mice (Li et al., 2013), suggesting that Wnt5a-Ror2 signaling might play an important role in disrupting TBM via MMP-2 during renal fibrosis. The gene discussed is MMP2; the disease is renal fibrosis.