WNT5A and colitis: A critical role of Wnt5a-Ror2 signaling has also been reported in the dextran sodium sulfate-induced colitis mouse model, where sustained up-regulation of Wnt5a can be observed in stromal fibroblasts in the ulcerative lesions of these mice, and Wnt5a-Ror2 signaling activated in dendritic cells can promote interferon-γ signaling, thereby promoting colitis (Sato et al., 2015).