Indeed, Ror2−/− and Wnt5a−/- mouse embryos exhibit dwarfism, short limbs and tail, facial anomalies, and ventricular septal defect (Yamaguchi et al., 1999; DeChiara et al., 2000; Takeuchi et al., 2000; Oishi et al., 2003; Schwabe et al., 2004; He et al., 2008), reminiscent of features observed in patients with Robinow syndrome that is caused by loss-of-function mutations in Ror2 or Wnt5a genes (Atalay et al., 1993; Afzal et al., 2000; van Bokhoven et al., 2000; Person et al., 2010). This evidence concerns the gene WNT5A and Robinow syndrome.