NLRP3 and endothelial dysfunction: Recent studies provided new evidence that NLRP3 inflammasome was activated due to the energy metabolism disorders in mitochondria and increased ROS in ApoE−/- mice and human artery endothelial cells (HAECs) treated with ox-LDL, which contributed to atherogenesis through causing endothelial dysfunction (Xie et al., 2020).