Sharma et al. found MCC950 ameliorated diabetes-caused AS by reducing inflammation and improving vascular function in the ApoE−/- mice treated with streptozotocin; additionally, in a range of cell lines (THP-1 cells, BMDM, aortic SMCs from humans with diabetes and phorbol 12-myristate 13-acetate-stimulated human macrophages), MCC950 markedly weakened caspase-1 and IL-1β secretion under high glucose or LPS stimulation (Sharma et al., 2021). This evidence concerns the gene APOE and diabetes mellitus.